About Me

A pragmatic IT leader with a track record of transforming systems, teams, and operating models.

Available for both consulting and full-time leadership roles

My Approach

I'm a decisive, execution-first IT leader who thrives in ambiguity. From rebuilding portfolio governance in a post-RIF environment to leading multi-million-dollar divestitures, I've delivered structure where there wasn't any—and built systems that scale even when headcount doesn't.

I started in the Army, worked my way through state systems and banking, then pivoted into biotech—eventually leading IT portfolio delivery at a public company. Along the way, I've rebuilt PMOs, delivered capital programs, executed divestitures, and scaled IT operations through layoffs, M&A, and FDA approval phases.

My effectiveness comes from bringing structure to shifting priorities, stepping into leadership vacuums, and moving work forward when others hesitate. I focus on impact, own results, and cut through noise. That's how I work—and how I help teams deliver during make-or-break transitions.

Nate Thompson professional photo

My Journey

From boots-on-the-ground support to boardroom strategy

09/2012 - 03/2016

Network Switching Systems Operator-Maintainer, U.S. Army

I led a team responsible for field communications infrastructure and tactical network operations. This experience developed my foundational discipline and troubleshooting instincts that have served as bedrock throughout my career.

10/2016 - 11/2017

System Support Specialist, Texas Department of Criminal Justice

I provided remote support to over 36,000 employees across 100+ prisons and created a comprehensive user manual for 3rd-shift technicians. I also developed user-friendly GUI applications using PowerShell and Visual Basic to streamline troubleshooting.

11/2017 - 05/2019

Team Leader - IT Service Delivery, Woodforest National Bank

I managed account provisioning and multi-platform user access workflows across the enterprise, supporting over 700 branch locations. I automated IT service tasks using custom tools and scripts, streamlining troubleshooting and reducing escalations.

06/2019 - 03/2021

IT Project Consultant/Team Leader, H3 Biomedicine

I delivered IT operations and infrastructure improvements, reduced paper waste by 20% through secure print systems, and led return-to-office tech efforts during COVID-19. I also upgraded legacy PBX and video conferencing infrastructure to cloud-based UCaaS solutions.

03/2021 - 01/2023

Manager, IT Program and Project Management, Seres Therapeutics

I led IT workstreams for five new facility buildouts over two years, including GMP manufacturing, labs, and office expansions. I delivered infrastructure and systems across R&D, Clinical, and GxP environments under a centralized capital program.

01/2023 - 01/2024

Senior Manager, IT Program and Project Management, Seres Therapeutics

I oversaw final facility buildout go-lives and supported FDA approval of VOWST, including the stabilization of key systems and infrastructure. I also managed IT program delivery during scale-down efforts and an enterprise-wide reduction in force.

01/2024 - Present

Associate Director, IT Portfolio Management & PMO, Seres Therapeutics

I'm currently leading portfolio execution across TSA divestiture efforts, covering infrastructure, data, and system transitions. I built the IT PMO function from the ground up, including its framework, governance model, and intake-to-execution workflows.

My Values

The principles that guide my approach to technology leadership

Execution Focus

I prioritize getting things done over perfect planning. While strategy matters, execution is where value is created. I build momentum through quick wins while keeping sight of long-term objectives.

Pragmatic Solutions

I believe in practical solutions that solve real problems. I focus on what works rather than what's trendy, balancing immediate needs with long-term scalability and sustainability.

People-Centered

Technology exists to serve people, not the other way around. I build systems and processes that empower teams, reduce friction, and create positive user experiences.

Career Goals

I'm passionate about helping organizations navigate critical technology transitions and build scalable systems that drive business outcomes. My career focus is on:

  • Providing strategic IT leadership to organizations navigating growth, change, or transformation
  • Building and optimizing IT portfolio management systems that deliver measurable business value
  • Developing teams that can execute effectively in ambiguous, fast-changing environments
  • Advancing to senior IT leadership positions or building a consulting practice focused on practical IT leadership
Nate Thompson

Let's Connect

Interested in working together or learning more about my approach?

Contact Me