Fractional CIO & IT Portfolio Leadership

Helping organizations navigate transitions, scale systems, and execute with clarity.

Available for both consulting and full-time leadership roles
Delivering
Nate Thompson

About Me

I'm a decisive, execution-first IT leader who thrives in ambiguity. From rebuilding portfolio governance in a post-RIF environment to leading multi-million-dollar divestitures, I've delivered structure where there wasn't any—and built systems that scale even when headcount doesn't.

My effectiveness comes from bringing structure to shifting priorities, stepping into leadership vacuums, and moving work forward when others hesitate. I focus on impact, own results, and cut through noise.

10+
Years Experience
$10M+
Portfolio Managed
5
Facilities Built
1
FDA Approval Supported

How I Can Help

Practical solutions for your technology leadership needs

Fractional CIO

Strategic technology leadership without the full-time executive cost. I provide the guidance, governance, and vision your organization needs.

IT Portfolio Management

Transform chaotic project execution into structured portfolio systems. I build governance models and execution frameworks.

Full-Time Leadership

Looking for a permanent technology leader? I'm open to full-time CIO, IT Director, or Portfolio Management roles.

Featured Case Studies

Real challenges, practical solutions, measurable results

Governance / Framework Design

Building the IT PMO from the Ground Up

Transformed chaotic project execution into a structured portfolio system—delivering visibility, governance, and efficiency in 60 days.

M&A / Transition Management

Managing Complex IT Divestiture

Led the IT workstream for a major divestiture, ensuring clean separation of systems, data, and infrastructure while maintaining business continuity.

My Experience

A track record of delivering results across industries

Associate Director, IT Portfolio Management & PMO

Seres Therapeutics
01/2024 to Present

Leading portfolio execution across TSA divestiture efforts - covering infrastructure, data, and system transitions.

  • Built the IT PMO function from the ground up, including its framework, governance model, and intake-to-execution workflows.
  • Established IT's formal project intake and prioritization structure, aligning all project efforts to both corporate objectives and departmental goals.
  • Created a standardized delivery model used by experienced PMs and non-PM business leads, with built-in tools and enablement to guide delivery.

Senior Manager, IT Program and Project Management

Seres Therapeutics
01/2023 to 01/2024

Oversaw final facility buildout go-lives and supported FDA approval of VOWST, including the stabilization of key systems and infrastructure.

  • Managed IT program delivery during scale-down efforts and an enterprise-wide reduction in force.
  • Supported internal reorganization efforts post-commercial launch, helping streamline project backlog and shift focus toward operational efficiency.

Ready to Fix the Chaos?

Let’s talk about how I can help your team simplify systems and lead through complexity—without the overhead.

Available for both consulting and full-time roles.